Stripp Lab

Lung Stem Cells and Airway Repair

Lung Stem Cells

We are interested in understanding basic mechanisms regulating epithelial maintenance and renewal in the pulmonary system. Our goal is to understand fundamental principles of tissue maintenance and repair that will be informative for development of new treatments for patients with lung disease. Ongoing research builds upon our initial discovery of resident lung stem cells and extends these observations to understand cellular and molecular mechanisms regulating their behavior in the intact lung and in culture. We use genetically modified animal models to manipulate and tag airway epithelial cell types, coupled with analysis of cell phenotype at the molecular level, to understand cellular behavior in normal and repairing states. For more detail on specific areas of research focus please click the Research tab below.