Note: For a complete listing of the lab's publications, click here to link out to the Pub Med publication search engine, and type in "Stripp, B". However, some of the notable lab publications are listed below.

 

Publications in the past year:

 

 

Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR. Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc. Natl. Acad. Sci. USA. (Epub 2009)

 

Snyder JC, Reynolds SD, Hollingsworth JW, Li Z, Kaminski N, Stripp BR. Clara cells attenuate the inflammatory response through regulation of macrophage behaviour. Am. J. Respir. Cell Mol. Biol. (Epub 2009)

 

Zemke, A.C., R. M. Teisanu, A. Giangreco, J. A. Drake, B. L. Brockway, S. D. Reynolds, and B. R. Stripp. Beta-catenin is not necessary for maintenance or repair of the bronchiolar epithelium. Am. J. Respir. Cell Mol. Biol. (Epub 2009).

 

Snyder JC, Teisanu RM, Stripp BR. Endogenous lung stem cells and contribution to disease. J Pathol. 2009;217:254-264.

Zemke, A.C., Snyder, J.C., Brockway, B.L., Drake, J.A., Reynolds, S.D., Kaminski, N., and Stripp, B.R. Molecular Staging of Epithlieial Maturation Using Secretory Cell-Specific Genes as Markers. Am J Respir Cell Mol Biol. 2008.

Teisanu, R.M., Lagasse, E., Whitesides, J.F., and Stripp, B.R. Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics. Stem Cells. 2008.

Stripp BR, Reynolds SD. Maintenance and repair of the bronchiolar epithelium. Proc Am Thorac Soc. 2008;5:328-333.

Stripp BR. Hierarchical Organization of Lung Progenitor Cells: Is there An Adult Lung Tissue Stem Cell? Proc Am Thorac Soc. 2008;5:695-698.

Snyder JC, Zemke AC, Stripp BR. Reparative Capacity of Airway Epithelium Impacts Deposition and Remodeling of Extracellular Matrix. Am J Respir Cell Mol Biol. 2008.

Reynolds, S.D., Zemke, A.C., Giangreco, A., Brockway, B.L., Teisanu, R.M., Drake, J.A., Mariani, T., Di, P.Y., Taketo, M.M., and Stripp, B.R. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells. 2008;26:1337-1346.

 

 

Selected Earlier Publications:

 

Reynolds, S.D., Reynolds, P.R., Snyder, J.C., Whyte, F., Paavola, K.J., and Stripp, B.R. CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. Am J Physiol Lung Cell Mol Physiol. 2007;293:L114-123.

This study provides direct evidence that Clara cell dysfunction leads to biochemical changes within lung monocyte/macrophages.

 

Plopper, C.G., Mango, G.W., Hatch, G.E., Wong, V.J., Toskala, E., Reynolds, S.D., Tarkington, B.K., and Stripp, B.R. Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein. Toxicol Appl Pharmacol. 2006;213:74-85.

This paper follows up on earlier work from this laboratory investigating roles for Clara cells in protection against oxidant lung pollutants such as ozone.

Hong, K.U., Reynolds, S.D., Watkins, S., Fuchs, E., and Stripp, B.R. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol. 2004;164:577-588.

 

Hong, K.U., Reynolds, S.D., Watkins, S., Fuchs, E., and Stripp, B.R. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol. 2004;286:L643-649.

These papers were the first such studies in the lung to use a transgenic approach involving ligand-regulated Cre recombinase to define lineage relationships within basal cells of the repairing proximal airway.

Giangreco A, Reynolds SD, Stripp BR. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol. 2002;161:173-182.

This paper defined the broncho-alveolar duct junction (BADJ) as a microenvironment (stem cell niche) that maintains bronchiolar stem cells.

Hong, K.U., Reynolds, S.D., Giangreco, A., Hurley, C.M., and Stripp, B.R. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am J Respir Cell Mol Biol. 2001;24:671-681.

This paper was the first to define a microenvironment within the bronchiole that maintains local tissue stem cells.

Reynolds, S.D., Hong, K.U., Giangreco, A., Mango, G.W., Guron, C., Morimoto, Y., and Stripp, B.R. Conditional Clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L1256-1263.

This was the first use of transgenic mice for conditional cell ablation. We were able to demonstrate a critical role for CCSP-expressing cells in bronchiolar repair.

Stripp, B. R., J. Lund, G. W. Mango, K. C. Doyen, C. Johnston, K. Hultenby, M. Nord, and J. A. Whitsett. Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. Am J Physiol. 1996; 271:L656-664.

This paper described the first knock-out model of a lung-specific gene. This model allowed us to reveal functional roles for Clara cells in lung homeostasis.

Stripp, B.R., Maxson, K., Mera, R., and Singh, G. Plasticity of airway cell proliferation and gene expression after acute naphthalene injury. Am J Physiol. 1995;269:L791-799.

In this paper we were able to reveal a unique pattern of airway repair following ablation of Clara cells that formed the basis for our evolving interest in bronchiolar stem cells and mechanisms of lung tissue repair.

Stripp BR, Huffman JA, Bohinski RJ. Structure and regulation of the murine Clara cell secretory protein gene. Genomics. 1994;20:27-35.

In this paper we provided details of the gene structure of the mouse CCSP gene and defined promoter elements that have subsequently been used to drive expression of transgenes within airway secreotry cells.

Stripp, B.R., Sawaya, P.L., Luse, D.S., Wikenheiser, K.A., Wert, S.E., Huffman, J.A., Lattier, D.L., Singh, G., Katyal, S.L., and Whitsett, J.A. cis-acting elements that confer lung epithelial cell expression of the CC10 gene. J Biol Chem. 1992;267:14703-14712.

This paper was one of the first to describe promoter elements of the rat CC10/CCSP gene that directed airway-specific gene expression in transgenic mice.